Gene causing anxiety and schizophrenia tracedDisorders Care

February 27, 2015 18:15

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Anxiety and schizophrenia will make human beings very different from normal persons, these diseases taking serious shape worldwide. Researchers at the University of California - Irvine and colleagues found the gene which alters the brain functioning in different circumstances.

The elicit behaviour of the human beings related to neuropsychiatric disease, causes by the gene called Gomafu, the outcome of the study might be key to understanding how our brain rapidly responds to stressful experiences.

"When Gomafu is turned off, this results in the kind of behavioural changes that are seen in anxiety and schizophrenia," said Timothy W Bredy, assistant professor of neurobiology and behaviour at UC Irvine.

This is the first time long, noncoding RNA activity has been detected in the brain in response to experience. "Early biologists thought that DNA sequences that do not make protein were remnants of our evolutionary history, but the fact is these sequences are actually highly dynamic and exert a profound influence on us," Bredy said.

Bredy and colleagues also found that non-coding genes such as Gomafu might represent a potent surveillance system that has evolved so that the brain can rapidly respond to changes in the environment.

He added that a disruption of this network in the brain might contribute to the development of neuropsychiatric disorders.

The study appears in the journal Biological Psychiatry.


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